SOCS2

GENERAL INFORMATION

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Gene name

SOCS2

Gene description

Suppressor of cytokine signaling 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate cytoplasmic staining was observed in a majority of normal cells. Neurons, gastric parietal cells, epididymis and seminiferus duct cells showed strong staining. Most lymphoid cells and squamous epithelial cells were weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB010356
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SOCS2 (HGNC Symbol)

Synonyms

CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2

Description

Suppressor of cytokine signaling 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

12

Cytoband

q22

Chromosome location (bp)

93569814 - 93583487

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120833 (version 78.38)

Entrez gene

8835

UniProt

O14508 (UniProt - Evidence at protein level)

neXtProt

NX_O14508

Antibodypedia

SOCS2 antibodies


PROTEIN BROWSER

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ENST00000340600
 
ENST00000536696
 
ENST00000547229
 
ENST00000548091
 
ENST00000548537
 
ENST00000549122
 
ENST00000549206
 
ENST00000549510
 
ENST00000549887
 
ENST00000551556
 
ENST00000551883
 
ENST00000622746
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS2-001 ENSP00000339428
ENST00000340600
O14508
Show all »
Show » Show » 198 22.2 No 0
SOCS2-002 ENSP00000448815
ENST00000549206
O14508
Show all »
Show » Show » 198 22.2 No 0
SOCS2-005 ENSP00000448709
ENST00000548537
F8VS53
Show all »
Show » Show » 102 11 No 0
SOCS2-006 ENSP00000447161
ENST00000549122
O14508
Show all »
Show » Show » 198 22.2 No 0
SOCS2-007 ENSP00000442898
ENST00000536696
O14508
Show all »
Show » Show » 198 22.2 No 0
SOCS2-008 ENSP00000447902
ENST00000548091
F8VU91
Show all »
Show » Show » 143 15.8 No 0
SOCS2-009 ENSP00000448611
ENST00000549887
F8VRV3
Show all »
Show » Show » 161 17.8 No 0
SOCS2-010 ENSP00000473902
ENST00000547229
Show » 3 0.4 No 0
SOCS2-011 ENSP00000449227
ENST00000551556
O14508
Show all »
Show » Show » 198 22.2 No 0
SOCS2-012 ENSP00000474805
ENST00000551883
Show » Show » 116 13.1 No 0
SOCS2-013 ENSP00000474888
ENST00000549510
Show » Show » 46 5.2 No 0
SOCS2-201 ENSP00000481249
ENST00000622746
O14508
Show all »
Show » Show » 198 22.2 No 0