DUSP4

GENE INFORMATION

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Gene name

DUSP4 (HGNC Symbol)

Synonyms

HVH2, MKP-2, TYP

Description

dual specificity phosphatase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

p12

Chromosome location (bp)

29190581 - 29208185

Ensembl

ENSG00000120875 (version 73.37)

Entrez gene

1846

UniProt

Q13115 (UniProt - Evidence at protein level)

neXtProt

NX_Q13115

Antibodypedia

DUSP4 antibodies
 

PROTEIN VIEW

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DUSP4-001
 
DUSP4-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP4-001 ENSP00000240100
ENST00000240100
Q13115
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Show » Show » 394 43 No 0
DUSP4-002 ENSP00000240101
ENST00000240101
Q13115
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Show » Show » 303 33 No 0