The Human Protein Atlas

GENE INFORMATION

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Gene name	ADRA1A (HGNC Symbol)
Synonyms	ADRA1C, ADRA1L1
Description	adrenoceptor alpha 1A (HGNC Symbol)
Entrez gene summary	Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Chromosome	8 (Chromosome progress)
Cytoband	p21.2
Chromosome location (bp)	26605667 - 26724790
Ensembl	ENSG00000120907 (version 69.37)
Entrez gene	148
UniProt	P35348
neXtProt	NX_P35348
Antibodypedia	ADRA1A antibodies

PROTEIN VIEW

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ADRA1A-001		ADRA1A-002		ADRA1A-003		ADRA1A-004		ADRA1A-005		ADRA1A-006		ADRA1A-007		ADRA1A-008		ADRA1A-009		ADRA1A-201		ADRA1A-202		ADRA1A-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ADRA1A-001	ENSP00000369956 ENST00000380582	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor Q7KYZ9 [Target identity:33%; Query identity:100%] Alpha 1c-adrenoceptor subtype protein	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 7TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	429	47.5	No	7
ADRA1A-002	ENSP00000346557 ENST00000354550	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor Q7KYZ9 [Target identity:31%; Query identity:100%] Alpha 1c-adrenoceptor subtype protein	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 7TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	455	50.8	No	7
ADRA1A-003	ENSP00000276393 ENST00000276393	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor Q6LD06 [Target identity:36%; Query identity:100%] Alpha-1c adrenergic receptor subtype Q7KYZ9 [Target identity:30%; Query identity:100%] Alpha 1c-adrenoceptor subtype protein	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 7TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	466	51.5	No	7
ADRA1A-004	ENSP00000369960 ENST00000380586	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor B0ZBD3 [Target identity:100%; Query identity:100%] Adrenergic, alpha-1A-, receptor variant 3 Q7KYZ9 [Target identity:30%; Query identity:100%] Alpha 1c-adrenoceptor subtype protein	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 7TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001985 [negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure] GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure] GO:0001996 [positive regulation of heart rate by epinephrine-norepinephrine] GO:0001997 [positive regulation of the force of heart contraction by epinephrine-norepinephrine] GO:0004937 [alpha1-adrenergic receptor activity] GO:0005624 [membrane fraction] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007512 [adult heart development] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0016049 [cell growth] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0035265 [organ growth] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0045987 [positive regulation of smooth muscle contraction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade] GO:0097195 [pilomotor reflex]	475	52.2	No	7
ADRA1A-005	ENSP00000369946 ENST00000380572	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 6TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	342	37.5	No	6
ADRA1A-006	ENSP00000430414 ENST00000521711	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 6TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	324	35.8	No	6
ADRA1A-007	ENSP00000431073 ENST00000519096	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 6TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	324	35.8	No	6
ADRA1A-008	ENSP00000369947 ENST00000380573	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor Q6LD06 [Target identity:36%; Query identity:100%] Alpha-1c adrenergic receptor subtype Q7KYZ9 [Target identity:30%; Query identity:100%] Alpha 1c-adrenoceptor subtype protein	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 7TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	466	51.5	No	7
ADRA1A-009	ENSP00000430793 ENST00000519229	E7EW16 Show all » « Hide E7EW16 [Target identity:100%; Query identity:100%] Alpha-1A adrenergic receptor Q7KYZ9 [Target identity:33%; Query identity:100%] Alpha 1c-adrenoceptor subtype protein	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 7TM proteins predicted by MDM	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005886 [plasma membrane] GO:0016021 [integral to membrane]	427	47.2	No	7
ADRA1A-201	ENSP00000351725 ENST00000358857	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 6TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	324	35.8	No	6
ADRA1A-202	ENSP00000369955 ENST00000380581	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 6TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	372	40.6	No	6
ADRA1A-203	ENSP00000369961 ENST00000380587	P35348 Show all » « Hide P35348 [Direct mapping] Alpha-1A adrenergic receptor	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins 6TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0004937 [alpha1-adrenergic receptor activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [elevation of cytosolic calcium ion concentration] GO:0007243 [intracellular protein kinase cascade] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone stimulus] GO:0031965 [nuclear membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042493 [response to drug] GO:0043410 [positive regulation of MAPK cascade] GO:0045760 [positive regulation of action potential] GO:0045907 [positive regulation of vasoconstriction] GO:0046982 [protein heterodimerization activity] GO:0060402 [calcium ion transport into cytosol] GO:0060452 [positive regulation of cardiac muscle contraction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling cascade]	370	40.7	No	6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.