TARDBP

GENE INFORMATION

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Gene name

TARDBP (HGNC Symbol)

Synonyms

ALS10, TDP-43

Description

TAR DNA binding protein (HGNC Symbol)

Entrez gene summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.22

Chromosome location (bp)

11072414 - 11085796

Ensembl

ENSG00000120948 (version 73.37)

Entrez gene

23435

UniProt

Q13148 (UniProt - Evidence at protein level)

neXtProt

NX_Q13148

Antibodypedia

TARDBP antibodies
 

PROTEIN VIEW

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TARDBP-001
 
TARDBP-002
 
TARDBP-003
 
TARDBP-004
 
TARDBP-005
 
TARDBP-006
 
TARDBP-007
 
TARDBP-008
 
TARDBP-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TARDBP-001 ENSP00000240185
ENST00000240185
Q13148
Show all »
Show » 414 44.7 No 0
TARDBP-002 ENSP00000432132
ENST00000473869
G3V162
Show all »
Show » 298 33.7 No 0
TARDBP-003 ENSP00000313129
ENST00000315091
B1AKP7
Show all »
Show » 295 33.5 No 0
TARDBP-004 ENSP00000465240
ENST00000473118
K7EJM5
Show all »
Show » 201 22.8 No 0
TARDBP-005 ENSP00000466842
ENST00000476201
K7EN94
Show all »
Show » Show » 222 25.1 No 0
TARDBP-006 ENSP00000465080
ENST00000472476
K7EJ99
Show all »
80 8.9 No 0
TARDBP-007 ENSP00000465888
ENST00000477447
65 6.9 No 0
TARDBP-008 ENSP00000467020
ENST00000496840
16 1.7 No 0
TARDBP-201 ENSP00000404666
ENST00000439080
B4DJ45
Show all »
Show » 298 31.8 No 0