COPS5

GENE INFORMATION

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Gene name

COPS5 (HGNC Symbol)

Synonyms

CSN5, JAB1, MOV-34, SGN5

Description

COP9 signalosome subunit 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

67955314 - 67996018

Ensembl

ENSG00000121022 (version 73.37)

Entrez gene

10987

UniProt

Q92905 (UniProt - Evidence at protein level)

neXtProt

NX_Q92905

Antibodypedia

COPS5 antibodies
 

PROTEIN VIEW

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COPS5-001
 
COPS5-004
 
COPS5-006
 
COPS5-008
 
COPS5-010
 
COPS5-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COPS5-001 ENSP00000350512
ENST00000357849
Q92905
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Show » Show » 334 37.6 No 0
COPS5-004 ENSP00000427869
ENST00000518374
E5RG35
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68 7.8 No 0
COPS5-006 ENSP00000428586
ENST00000518747
E5RHF2
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Show » 151 16.6 No 0
COPS5-008 ENSP00000428124
ENST00000517406
E5RK55
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78 9 No 0
COPS5-010 ENSP00000429774
ENST00000517736
E5RHH5
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Show » 197 22.2 No 0
COPS5-012 ENSP00000427997
ENST00000523890
E5RFS1
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57 6.3 No 0