ABCC11

GENE INFORMATION

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Gene name

ABCC11 (HGNC Symbol)

Synonyms

MRP8

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q12.1

Chromosome location (bp)

48200821 - 48281479

Ensembl

ENSG00000121270 (version 73.37)

Entrez gene

85320

UniProt

Q96J66 (UniProt - Evidence at protein level)

neXtProt

NX_Q96J66

Antibodypedia

ABCC11 antibodies
 

PROTEIN VIEW

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ABCC11-001
 
ABCC11-002
 
ABCC11-004
 
ABCC11-006
 
ABCC11-201
 
ABCC11-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC11-001 ENSP00000349017
ENST00000356608
Q96J66
Show all »
Show » Show » 1382 154.3 No >9
ABCC11-002 ENSP00000311326
ENST00000353782
Q96J66
Show all »
Show » Show » 1344 150.1 No >9
ABCC11-004 ENSP00000378230
ENST00000394747
Q96J66
Show all »
Show » Show » 1382 154.3 No >9
ABCC11-006 ENSP00000456268
ENST00000569991
H3BRJ2
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159 18.1 No 0
ABCC11-201 ENSP00000378231
ENST00000394748
Q96J66
Show all »
Show » Show » 1382 154.3 No >9
ABCC11-202 ENSP00000438530
ENST00000537808
F5H410
Show all »
Show » Show » 755 84.4 No 5