PSPC1

GENERAL INFORMATION

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Gene name

PSPC1

Gene description

Paraspeckle component 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in a majority of tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA038904
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PSPC1 (HGNC Symbol)

Synonyms

FLJ10955, PSP1

Description

Paraspeckle component 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

Chromosome

13

Cytoband

q12.11

Chromosome location (bp)

19674752 - 19783019

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121390 (version 78.38)

Entrez gene

55269

UniProt

Q8WXF1 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WXF1

Antibodypedia

PSPC1 antibodies


PROTEIN BROWSER

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ENST00000338910
 
ENST00000427943
 
ENST00000619300
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSPC1-002 ENSP00000343966
ENST00000338910
Q8WXF1
Show all »
Show » Show » 523 58.7 No 0
PSPC1-004 ENSP00000393069
ENST00000427943
X6RDA4
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Show » Show » 248 27.3 No 0
PSPC1-201 ENSP00000481916
ENST00000619300
Q8WXF1
Show all »
Show » Show » 523 58.7 No 0