MAPK8IP1

GENERAL INFORMATION

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Gene name

MAPK8IP1

Gene description

Mitogen-activated protein kinase 8 interacting protein 1

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A majority of normal cells displayed moderate to strong cytoplasmic positivity. Strong staining was for example observed in squamous epithelial cells, sub-set of cells in CNS, Leydig cells, glandular cells of epididymis and seminal vesicle.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB013289
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAPK8IP1 (HGNC Symbol)

Synonyms

IB1, JIP-1, JIP1, PRKM8IP

Description

Mitogen-activated protein kinase 8 interacting protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

45885651 - 45906465

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121653 (version 78.38)

Entrez gene

9479

UniProt

Q9UQF2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQF2

Antibodypedia

MAPK8IP1 antibodies


PROTEIN BROWSER

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ENST00000241014
 
ENST00000395629
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK8IP1-001 ENSP00000241014
ENST00000241014
Q9UQF2
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Show » Show » 711 77.5 No 0
MAPK8IP1-003 ENSP00000378991
ENST00000395629
E9PBB9
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Show » Show » 701 77.2 No 0