CCR2

GENE INFORMATION

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Gene name

CCR2 (HGNC Symbol)

Synonyms

CC-CKR-2, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R

Description

chemokine (C-C motif) receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

46395225 - 46402419

Ensembl

ENSG00000121807 (version 73.37)

Entrez gene

729230

UniProt

P41597 (UniProt - Evidence at protein level)

neXtProt

NX_P41597

Antibodypedia

CCR2 antibodies
 

PROTEIN VIEW

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CCR2-001
 
CCR2-002
 
CCR2-004
 
CCR2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR2-001 ENSP00000383681
ENST00000400888
P41597
Show all »
Show » Show » 374 41.9 No 6
CCR2-002 ENSP00000399285
ENST00000445132
P41597
Show all »
Show » Show » 360 41.1 No 7
CCR2-004 ENSP00000396736
ENST00000421659
E9PH76
Show all »
Show » Show » 121 13.7 No 2
CCR2-201 ENSP00000292301
ENST00000292301
P41597
Show all »
Show » Show » 374 41.9 No 6