ADORA3

GENERAL INFORMATION

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Gene name

ADORA3

Gene description

Adenosine A3 receptor

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in a subset of tissues including Leydig cells, adrenal gland and squamous epithelia.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 3 antibodies.
HPA028509 , HPA028566 , HPA028568
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

ADORA3 (HGNC Symbol)

Synonyms

AD026

Description

Adenosine A3 receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

Chromosome

1

Cytoband

p13.2

Chromosome location (bp)

111483348 - 111563962

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121933 (version 78.38)

Entrez gene

140

UniProt

P33765 (UniProt - Evidence at transcript level), Q6P2N6 (UniProt - Evidence at transcript level)

neXtProt

NX_P33765, NX_Q6P2N6

Antibodypedia

ADORA3 antibodies


PROTEIN BROWSER

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ENST00000241356
 
ENST00000369716
 
ENST00000369717
 
ENST00000414219
 
ENST00000442484
 
ENST00000443498
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADORA3-001 ENSP00000358731
ENST00000369717
Q6P2N6
Show all »
Show » Show » 266 30.3 No 2
ADORA3-002 ENSP00000406102
ENST00000442484
Show » 115 12.7 No 0
ADORA3-003 ENSP00000415646
ENST00000414219
Show » 207 23.4 No 1
ADORA3-006 ENSP00000398770
ENST00000443498
Q5QNY8
Show all »
Show » 172 19.6 No 1
ADORA3-007 ENSP00000358730
ENST00000369716
P33765
Show all »
Show » Show » 347 39 No 5
ADORA3-010 ENSP00000241356
ENST00000241356
P33765
Show all »
Show » Show » 318 36.2 No 7