CXCR4

GENE INFORMATION

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Gene name

CXCR4 (HGNC Symbol)

Synonyms

CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R

Description

chemokine (C-X-C motif) receptor 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

136871919 - 136875735

Ensembl

ENSG00000121966 (version 73.37)

Entrez gene

7852

UniProt

P61073 (UniProt - Evidence at protein level)

neXtProt

NX_P61073

Antibodypedia

CXCR4 antibodies
 

PROTEIN VIEW

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CXCR4-001
 
CXCR4-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCR4-001 ENSP00000241393
ENST00000241393
P61073
Show all »
Show » Show » 352 39.7 No 7
CXCR4-003 ENSP00000386884
ENST00000409817
P61073
Show all »
Show » Show » 356 40.2 No 7