ACVR2A

GENE INFORMATION

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Gene name

ACVR2A (HGNC Symbol)

Synonyms

ACTRII, ACVR2

Description

activin A receptor, type IIA (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Chromosome

2 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

148602086 - 148688393

Ensembl

ENSG00000121989 (version 73.37)

Entrez gene

92

UniProt

P27037 (UniProt - Evidence at protein level)

neXtProt

NX_P27037

Antibodypedia

ACVR2A antibodies
 

PROTEIN VIEW

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ACVR2A-001
 
ACVR2A-002
 
ACVR2A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR2A-001 ENSP00000241416
ENST00000241416
P27037
Show all »
Show » Show » 513 57.8 Yes 1
ACVR2A-002 ENSP00000384338
ENST00000404590
P27037
Show all »
Show » Show » 513 57.8 Yes 1
ACVR2A-201 ENSP00000439988
ENST00000535787
B4DWQ2
Show all »
Show » Show » 405 45.7 No 1