FLT3

GENE INFORMATION

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Gene name

FLT3 (HGNC Symbol)

Synonyms

CD135, FLK2, STK1

Description

fms-related tyrosine kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]

Chromosome

13 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

28577411 - 28674729

Ensembl

ENSG00000122025 (version 73.37)

Entrez gene

2322

UniProt

P36888 (UniProt - Evidence at protein level)

neXtProt

NX_P36888

Antibodypedia

FLT3 antibodies
 

PROTEIN VIEW

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FLT3-001
 
FLT3-002
 
FLT3-201
 
FLT3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FLT3-001 ENSP00000241453
ENST00000241453
P36888
Show all »
Show » Show » 993 112.9 No 1
FLT3-002 ENSP00000370374
ENST00000380987
E7ER61
Show all »
Show » Show » 739 83.8 No 1
FLT3-201 ENSP00000370369
ENST00000380982
Q5VTU6
Show all »
Show » Show » 996 113.3 No 1
FLT3-202 ENSP00000438139
ENST00000537084
P36888
Show all »
Show » Show » 952 108.4 No 1