OPN4

GENERAL INFORMATION

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Gene name

OPN4

Gene description

Opsin 4

Protein class

G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx:Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein localization

External data suggests expression in retina. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

No internal RNA expression data available for correlation. Presumed off target binding observed and disregarded. Pending additional tissues.

Data reliability

Uncertain based on 1 antibody.
HPA039147
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, skeletal muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue)

Organ

Expression



GENE INFORMATION

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Gene name

OPN4 (HGNC Symbol)

Synonyms

melanopsin, MOP

Description

Opsin 4 (HGNC Symbol)

Entrez gene summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q23.2

Chromosome location (bp)

86654557 - 86666848

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122375 (version 78.38)

Entrez gene

94233

UniProt

Q9UHM6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UHM6

Antibodypedia

OPN4 antibodies


PROTEIN BROWSER

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ENST00000241891
 
ENST00000372071
 
ENST00000443292
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OPN4-001 ENSP00000241891
ENST00000241891
Q9UHM6
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Show » Show » 478 52.6 No 6
OPN4-002 ENSP00000393132
ENST00000443292
C9JWU6
Show all »
Show » Show » 495 54.5 No 6
OPN4-201 ENSP00000361141
ENST00000372071
Q9UHM6
Show all »
Show » Show » 489 53.8 No 6