OPN4

GENE INFORMATION

? »

Gene name

OPN4 (HGNC Symbol)

Synonyms

melanopsin, MOP

Description

opsin 4 (HGNC Symbol)

Entrez gene summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

88414314 - 88426605

Ensembl

ENSG00000122375 (version 73.37)

Entrez gene

94233

UniProt

Q9UHM6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UHM6

Antibodypedia

OPN4 antibodies
 

PROTEIN VIEW

? »
 
 
 
OPN4-001
 
OPN4-002
 
OPN4-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OPN4-001 ENSP00000241891
ENST00000241891
Q9UHM6
Show all »
Show » Show » 478 52.6 No 6
OPN4-002 ENSP00000393132
ENST00000443292
C9JWU6
Show all »
Show » Show » 495 54.5 No 6
OPN4-201 ENSP00000361141
ENST00000372071
Q9UHM6
Show all »
Show » Show » 489 53.8 No 6