INHBA

GENERAL INFORMATION

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Gene name

INHBA

Gene description

Inhibin, beta A

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (gallbladder)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA020031
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

INHBA

Synonyms

Description

Inhibin, beta A (HGNC Symbol)

Entrez gene summary

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p14.1

Chromosome location (bp)

41685114 - 41703108

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122641 (version 78.38)

Entrez gene

3624

UniProt

P08476 (UniProt - Evidence at protein level)

neXtProt

NX_P08476

Antibodypedia

INHBA antibodies


PROTEIN BROWSER

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ENST00000242208
 
ENST00000442711
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INHBA-001 ENSP00000242208
ENST00000242208
P08476
Show all »
Show » Show » 426 47.4 Yes 0
INHBA-002 ENSP00000397197
ENST00000442711
P08476
Show all »
Show » Show » 426 47.4 Yes 0