INHBA

GENE INFORMATION

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Gene name

INHBA

Synonyms

Description

inhibin, beta A (HGNC Symbol)

Entrez gene summary

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

p14.1

Chromosome location (bp)

41724712 - 41742706

Ensembl

ENSG00000122641 (version 73.37)

Entrez gene

3624

UniProt

P08476 (UniProt - Evidence at protein level)

neXtProt

NX_P08476

Antibodypedia

INHBA antibodies
 

PROTEIN VIEW

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INHBA-001
 
INHBA-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INHBA-001 ENSP00000242208
ENST00000242208
P08476
Show all »
Show » Show » 426 47.4 Yes 0
INHBA-002 ENSP00000397197
ENST00000442711
P08476
Show all »
Show » Show » 426 47.4 Yes 0