ACO1

GENE INFORMATION

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Gene name

ACO1 (HGNC Symbol)

Synonyms

IREB1, IREBP, IRP1

Description

aconitase 1, soluble (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

9 (Chromosome progress)

Cytoband

p21.1

Chromosome location (bp)

32384618 - 32450834

Ensembl

ENSG00000122729 (version 73.37)

Entrez gene

48

UniProt

P21399 (UniProt - Evidence at protein level)

neXtProt

NX_P21399

Antibodypedia

ACO1 antibodies
 

PROTEIN VIEW

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ACO1-001
 
ACO1-002
 
ACO1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACO1-001 ENSP00000309477
ENST00000309951
P21399
Show all »
Show » Show » 889 98.4 No 0
ACO1-002 ENSP00000369255
ENST00000379923
P21399
Show all »
Show » Show » 889 98.4 No 0
ACO1-201 ENSP00000438733
ENST00000541043
Q9HBB2
Show all »
Show » Show » 790 87.1 No 0