PLAU

GENE INFORMATION

? »

Gene name

PLAU (HGNC Symbol)

Synonyms

UPA, URK

Description

plasminogen activator, urokinase (HGNC Symbol)

Entrez gene summary

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Chromosome

10 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

75668935 - 75677255

Ensembl

ENSG00000122861 (version 73.37)

Entrez gene

5328

UniProt

P00749 (UniProt - Evidence at protein level)

neXtProt

NX_P00749

Antibodypedia

PLAU antibodies
 

PROTEIN VIEW

? »
 
 
 
PLAU-001
 
PLAU-004
 
PLAU-201
 
PLAU-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLAU-001 ENSP00000361850
ENST00000372764
P00749
Show all »
Show » Show » 431 48.5 Yes 0
PLAU-004 ENSP00000474318
ENST00000481390
Show » 106 11.8 Yes 0
PLAU-201 ENSP00000361848
ENST00000372762
E7ESM2
Show all »
Show » Show » 395 44.6 Yes 0
PLAU-202 ENSP00000388474
ENST00000446342
E7ET40
Show all »
Show » Show » 414 46.9 No 0