P4HA1

GENE INFORMATION

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Gene name

P4HA1 (HGNC Symbol)

Synonyms

C-P4Halpha(I), P4HA

Description

prolyl 4-hydroxylase, alpha polypeptide I (HGNC Symbol)

Entrez gene summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

74766975 - 74856732

Ensembl

ENSG00000122884 (version 73.37)

Entrez gene

5033

UniProt

P13674 (UniProt - Evidence at protein level)

neXtProt

NX_P13674

Antibodypedia

P4HA1 antibodies
 

PROTEIN VIEW

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P4HA1-001
 
P4HA1-002
 
P4HA1-201
 
P4HA1-202
 
P4HA1-203
 
P4HA1-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P4HA1-001 ENSP00000307318
ENST00000307116
P13674
Show all »
Show » Show » 534 61 Yes 0
P4HA1-002 ENSP00000362099
ENST00000373008
P13674
Show all »
Show » Show » 534 61 Yes 0
P4HA1-201 ENSP00000263556
ENST00000263556
P13674
Show all »
Show » Show » 534 61 Yes 0
P4HA1-202 ENSP00000378353
ENST00000394890
P13674
Show all »
Show » Show » 534 61 Yes 0
P4HA1-203 ENSP00000411688
ENST00000412021
P13674
Show all »
Show » Show » 534 61 Yes 0
P4HA1-204 ENSP00000414464
ENST00000440381
P13674
Show all »
Show » Show » 516 59 Yes 0