CIT

GENE INFORMATION

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Gene name

CIT (HGNC Symbol)

Synonyms

CRIK, KIAA0949, STK21

Description

Citron (rho-interacting, serine/threonine kinase 21) (HGNC Symbol)

Entrez gene summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Chromosome

12

Cytoband

q24.23

Chromosome location (bp)

120123595 - 120315095

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122966 (version 75.37)

Entrez gene

100302274

UniProt

O14578 (UniProt - Evidence at protein level)

neXtProt

NX_O14578

Antibodypedia

CIT antibodies
 

PROTEIN VIEW

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CIT-001
 
CIT-005
 
CIT-006
 
CIT-008
 
CIT-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CIT-001 ENSP00000261833
ENST00000261833
O14578
Show all »
Show » Show » 2027 231.4 No 0
CIT-005 ENSP00000376306
ENST00000392521
O14578
Show all »
Show » Show » 2069 236.6 No 0
CIT-006 ENSP00000376305
ENST00000392520
Show » Show » 1640 187.3 No 0
CIT-008 ENSP00000443199
ENST00000536325
H0YGG8
Show all »
Show » Show » 109 12.6 No 0
CIT-011 ENSP00000446105
ENST00000546026
F5H4K4
Show all »
Show » Show » 162 18.8 No 0