PKN1

GENE INFORMATION

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Gene name

PKN1 (HGNC Symbol)

Synonyms

DBK, MGC46204, PAK1, PKN, PRK1, PRKCL1

Description

protein kinase N1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.12

Chromosome location (bp)

14543865 - 14582679

Ensembl

ENSG00000123143 (version 73.37)

Entrez gene

5585

UniProt

Q16512 (UniProt - Evidence at protein level)

neXtProt

NX_Q16512

Antibodypedia

PKN1 antibodies
 

PROTEIN VIEW

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PKN1-001
 
PKN1-002
 
PKN1-004
 
PKN1-005
 
PKN1-006
 
PKN1-010
 
PKN1-011
 
PKN1-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKN1-001 ENSP00000242783
ENST00000242783
Q16512
Show all »
Show » Show » 942 103.9 No 0
PKN1-002 ENSP00000343325
ENST00000342216
Q16512
Show all »
Show » Show » 948 104.7 No 0
PKN1-004 ENSP00000467422
ENST00000585619
15 1.7 No 0
PKN1-005 ENSP00000465842
ENST00000586557
K7EKY9
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Show » 256 28.3 No 0
PKN1-006 ENSP00000466367
ENST00000590097
K7EM57
Show all »
Show » 263 29 No 0
PKN1-010 ENSP00000466819
ENST00000586237
K7EN76
Show all »
151 15.7 No 0
PKN1-011 ENSP00000465867
ENST00000591461
K7EL10
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Show » 198 21.7 No 0
PKN1-013 ENSP00000468497
ENST00000592960
226 24.2 No 0