CD97

GENE INFORMATION

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Gene name

CD97 (HGNC Symbol)

Synonyms

TM7LN1

Description

CD97 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Chromosome

19 (Chromosome progress)

Cytoband

p13.12

Chromosome location (bp)

14491313 - 14519537

Ensembl

ENSG00000123146 (version 73.37)

Entrez gene

976

UniProt

P48960 (UniProt - Evidence at protein level)

neXtProt

NX_P48960

Antibodypedia

CD97 antibodies
 

PROTEIN VIEW

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CD97-001
 
CD97-002
 
CD97-003
 
CD97-006
 
CD97-008
 
CD97-009
 
CD97-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD97-001 ENSP00000351413
ENST00000358600
P48960
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Show » Show » 742 81.7 Yes 7
CD97-002 ENSP00000349918
ENST00000357355
P48960
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Show » Show » 786 86.6 Yes 7
CD97-003 ENSP00000242786
ENST00000242786
P48960
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Show » Show » 835 91.9 Yes 7
CD97-006 ENSP00000465800
ENST00000587606
K7EKV5
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Show » Show » 154 16.6 Yes 0
CD97-008 ENSP00000467351
ENST00000586517
K7EPE8
Show all »
Show » 157 17.1 No 0
CD97-009 ENSP00000466040
ENST00000591080
K7ELE5
Show all »
Show » Show » 149 16.1 Yes 0
CD97-010 ENSP00000467478
ENST00000592261
K7EPP8
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Show » 164 17.6 Yes 0