NLN

GENERAL INFORMATION

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Gene name

NLN

Gene description

Neurolysin (metallopeptidase M3 family)

Protein class

Enzymes
Mitochondrial proteins
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA031862
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NLN (HGNC Symbol)

Synonyms

AGTBP, KIAA1226

Description

Neurolysin (metallopeptidase M3 family) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

Chromosome

5

Cytoband

q12.3

Chromosome location (bp)

65722196 - 65871725

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123213 (version 78.38)

Entrez gene

57486

UniProt

Q9BYT8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BYT8

Antibodypedia

NLN antibodies


PROTEIN BROWSER

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ENST00000380985
 
ENST00000502464
 
ENST00000509935
 
ENST00000511299
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NLN-001 ENSP00000370372
ENST00000380985
Q9BYT8
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Show » Show » 704 80.7 No 0
NLN-003 ENSP00000427417
ENST00000511299
H0YAK4
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Show » Show » 414 46.9 No 0
NLN-009 ENSP00000426959
ENST00000509935
H0YAF7
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Show » Show » 283 31.7 No 0
NLN-010 ENSP00000423214
ENST00000502464
E9PCB6
Show all »
Show » Show » 600 68.9 No 0