ATF1

GENERAL INFORMATION

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Gene name

ATF1

Gene description

Activating transcription factor 1

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA055069 , CAB016222
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATF1 (HGNC Symbol)

Synonyms

TREB36

Description

Activating transcription factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Chromosome

12

Cytoband

q13.12

Chromosome location (bp)

50763710 - 50821122

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123268 (version 78.38)

Entrez gene

466

UniProt

P18846 (UniProt - Evidence at protein level)

neXtProt

NX_P18846

Antibodypedia

ATF1 antibodies


PROTEIN BROWSER

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ENST00000262053
 
ENST00000552487
 
ENST00000552510
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF1-001 ENSP00000262053
ENST00000262053
P18846
Show all »
Show » Show » 271 29.2 No 0
ATF1-003 ENSP00000448592
ENST00000552510
F8VS03
Show all »
Show » Show » 170 17.7 No 0
ATF1-004 ENSP00000448921
ENST00000552487
F8VYN3
Show all »
Show » Show » 200 20.8 No 0