ATF1

GENE INFORMATION

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Gene name

ATF1 (HGNC Symbol)

Synonyms

TREB36

Description

activating transcription factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q13.12

Chromosome location (bp)

51157493 - 51214905

Ensembl

ENSG00000123268 (version 73.37)

Entrez gene

466

UniProt

P18846 (UniProt - Evidence at protein level)

neXtProt

NX_P18846

Antibodypedia

ATF1 antibodies
 

PROTEIN VIEW

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ATF1-001
 
ATF1-002
 
ATF1-003
 
ATF1-004
 
ATF1-005
 
ATF1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF1-001 ENSP00000262053
ENST00000262053
P18846
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Show » Show » 271 29.2 No 0
ATF1-002 ENSP00000448987
ENST00000551831
F8VYE5
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Show » 55 6.3 No 0
ATF1-003 ENSP00000448592
ENST00000552510
F8VS03
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Show » Show » 170 17.7 No 0
ATF1-004 ENSP00000448921
ENST00000552487
F8VYN3
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Show » Show » 200 20.8 No 0
ATF1-005 ENSP00000448421
ENST00000549612
F8VRN2
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Show » 77 7.9 No 0
ATF1-201 ENSP00000438403
ENST00000539132
B4DRF9
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Show » Show » 136 15.3 No 0