The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients).
By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
A few cases of hepatocellular carcinomas and occasional cases of gliomas and urothelial cancers showed moderate cytoplasmic staining while a single each of hepatocellular carcinoma and adenocarcinoma of head and neck cancer showed strong positivity. Several cases of prostate cancers displayed moderate cytoplasmic, membranous and nuclear positivity. Few cases of malignant melanomas, papillary adenocarcinomas of thyroid and ovarian cancers displayed moderate cytoplasmic and nuclear staining. Remaining malignant tissues were weakly stained or negative.
One antibody yielding a staining pattern and there is no available gene/protein characterization data or the staining pattern is partly consistent with or contradicted by limited gene/protein characterization data
Level of antibody staining/expression
High Medium Low Not detected
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.