CDK2

GENE INFORMATION

? »

Gene name

CDK2

Synonyms

Description

cyclin-dependent kinase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

56360553 - 56366568

Ensembl

ENSG00000123374 (version 73.37)

Entrez gene

1017

UniProt

P24941 (UniProt - Evidence at protein level)

neXtProt

NX_P24941

Antibodypedia

CDK2 antibodies
 

PROTEIN VIEW

? »
 
 
 
CDK2-001
 
CDK2-002
 
CDK2-003
 
CDK2-004
 
CDK2-006
 
CDK2-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK2-001 ENSP00000266970
ENST00000266970
P24941
Show all »
Show » Show » 298 33.9 No 0
CDK2-002 ENSP00000243067
ENST00000354056
P24941
Show all »
Show » Show » 264 30 No 0
CDK2-003 ENSP00000393605
ENST00000440311
E7ESI2
Show all »
Show » 238 27.2 No 0
CDK2-004 ENSP00000452138
ENST00000555357
G3V317
Show all »
Show » 39 4.4 No 0
CDK2-006 ENSP00000450983
ENST00000555408
G3V317
Show all »
Show » 39 4.4 No 0
CDK2-007 ENSP00000452514
ENST00000553376
G3V5T9
Show all »
Show » Show » 346 39.2 No 0