LRP1

GENE INFORMATION

? »

Gene name

LRP1 (HGNC Symbol)

Synonyms

A2MR, APOER, APR, CD91, LRP, LRP1A

Description

low density lipoprotein receptor-related protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

57522276 - 57607134

Ensembl

ENSG00000123384 (version 73.37)

Entrez gene

4035

UniProt

Q07954 (UniProt - Evidence at protein level)

neXtProt

NX_Q07954

Antibodypedia

LRP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
LRP1-001
 
LRP1-002
 
LRP1-003
 
LRP1-004
 
LRP1-009
 
LRP1-012
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRP1-001 ENSP00000243077
ENST00000243077
Q07954
Show all »
Show » Show » 4544 504.6 Yes 1
LRP1-002 ENSP00000451449
ENST00000553277
Q7Z7K9
Show all »
Show » 296 32.2 Yes 0
LRP1-003 ENSP00000341264
ENST00000338962
Q86SW0
Show all »
Show » 292 31.6 Yes 0
LRP1-004 ENSP00000451737
ENST00000554174
Q6PJ72
Show all »
Show » 439 48.2 Yes 0
LRP1-009 ENSP00000451012
ENST00000555124
H0YJ88
Show all »
Show » 183 20.6 No 0
LRP1-012 ENSP00000451622
ENST00000554118
139 15.4 No 0