STIL

GENE INFORMATION

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Gene name

STIL (HGNC Symbol)

Synonyms

MCPH7, SIL

Description

SCL/TAL1 interrupting locus (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p33

Chromosome location (bp)

47715811 - 47779819

Ensembl

ENSG00000123473 (version 73.37)

Entrez gene

6491

UniProt

Q15468 (UniProt - Evidence at protein level)

neXtProt

NX_Q15468

Antibodypedia

STIL antibodies
 

PROTEIN VIEW

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STIL-001
 
STIL-002
 
STIL-004
 
STIL-005
 
STIL-006
 
STIL-008
 
STIL-201
 
STIL-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STIL-001 ENSP00000353544
ENST00000360380
Q15468
Show all »
Show » Show » 1287 143 No 0
STIL-002 ENSP00000411664
ENST00000447475
Q5T0C7
Show all »
Show » 918 102.2 No 0
STIL-004 ENSP00000360944
ENST00000371877
Q15468
Show all »
Show » Show » 1288 143 No 0
STIL-005 ENSP00000412019
ENST00000413565
Q5T0C8
Show all »
Show » 92 10.6 No 0
STIL-006 ENSP00000409087
ENST00000436811
Q5T0D4
Show all »
Show » 211 23 No 0
STIL-008 ENSP00000379523
ENST00000396221
E9PSF2
Show all »
Show » 1270 141.1 No 0
STIL-201 ENSP00000243182
ENST00000243182
Q15468
Show all »
Show » Show » 1287 143 No 0
STIL-202 ENSP00000337367
ENST00000337817
Q15468
Show all »
Show » Show » 1287 143 No 0