ACVR1C

GENE INFORMATION

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Gene name

ACVR1C (HGNC Symbol)

Synonyms

ACVRLK7, ALK7

Description

activin A receptor, type IC (HGNC Symbol)

Entrez gene summary

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

158388888 - 158485517

Ensembl

ENSG00000123612 (version 73.37)

Entrez gene

130399

UniProt

Q8NER5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NER5

Antibodypedia

ACVR1C antibodies
 

PROTEIN VIEW

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ACVR1C-001
 
ACVR1C-002
 
ACVR1C-003
 
ACVR1C-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR1C-001 ENSP00000243349
ENST00000243349
Q8NER5
Show all »
Show » Show » 493 54.9 Yes 1
ACVR1C-002 ENSP00000335139
ENST00000348328
Q8NER5
Show all »
Show » Show » 336 37.5 Yes 0
ACVR1C-003 ENSP00000335178
ENST00000335450
Q8NER5
Show all »
Show » Show » 413 46.4 Yes 0
ACVR1C-004 ENSP00000387168
ENST00000409680
Q8NER5
Show all »
Show » Show » 443 49.7 No 1