PLCG1

GENE INFORMATION

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Gene name

PLCG1 (HGNC Symbol)

Synonyms

NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1

Description

phospholipase C, gamma 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

39765600 - 39811629

Ensembl

ENSG00000124181 (version 73.37)

Entrez gene

5335

UniProt

P19174 (UniProt - Evidence at protein level)

neXtProt

NX_P19174

Antibodypedia

PLCG1 antibodies
 

PROTEIN VIEW

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PLCG1-005
 
PLCG1-013
 
PLCG1-014
 
PLCG1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLCG1-005 ENSP00000362368
ENST00000373271
P19174
Show all »
Show » Show » 1290 148.5 No 0
PLCG1-013 ENSP00000244007
ENST00000244007
P19174
Show all »
Show » Show » 1291 148.7 No 0
PLCG1-014 ENSP00000468958
ENST00000599785
M0QX77
Show all »
Show » 50 5.6 No 0
PLCG1-201 ENSP00000362369
ENST00000373272
P19174
Show all »
Show » Show » 1291 148.7 No 0