ARFGEF2

GENERAL INFORMATION

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Gene name

ARFGEF2

Gene description

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA026078 , CAB026382
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ARFGEF2 (HGNC Symbol)

Synonyms

BIG2

Description

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (HGNC Symbol)

Entrez gene summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

48921890 - 49036693

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124198 (version 78.38)

Entrez gene

10564

UniProt

Q9Y6D5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6D5

Antibodypedia

ARFGEF2 antibodies


PROTEIN BROWSER

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ENST00000371917
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARFGEF2-001 ENSP00000360985
ENST00000371917
Q9Y6D5
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