ARFGEF2

GENE INFORMATION

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Gene name

ARFGEF2 (HGNC Symbol)

Synonyms

BIG2

Description

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (HGNC Symbol)

Entrez gene summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

47538427 - 47653230

Ensembl

ENSG00000124198 (version 73.37)

Entrez gene

10564

UniProt

Q9Y6D5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6D5

Antibodypedia

ARFGEF2 antibodies
 

PROTEIN VIEW

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ARFGEF2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARFGEF2-001 ENSP00000360985
ENST00000371917
Q9Y6D5
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