STAU1

GENE INFORMATION

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Gene name

STAU1 (HGNC Symbol)

Synonyms

STAU

Description

staufen double-stranded RNA binding protein 1 (HGNC Symbol)

Entrez gene summary

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

47729878 - 47804904

Ensembl

ENSG00000124214 (version 73.37)

Entrez gene

6780

UniProt

O95793 (UniProt - Evidence at protein level)

neXtProt

NX_O95793

Antibodypedia

STAU1 antibodies
 

PROTEIN VIEW

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STAU1-001
 
STAU1-002
 
STAU1-003
 
STAU1-004
 
STAU1-005
 
STAU1-006
 
STAU1-007
 
STAU1-008
 
STAU1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAU1-001 ENSP00000360922
ENST00000371856
O95793
Show all »
Show » 577 63.2 No 0
STAU1-002 ENSP00000353604
ENST00000360426
O95793
Show all »
Show » 496 54.9 No 0
STAU1-003 ENSP00000323443
ENST00000347458
O95793
Show all »
Show » 496 54.9 No 0
STAU1-004 ENSP00000345425
ENST00000340954
O95793
Show all »
Show » 496 54.9 No 0
STAU1-005 ENSP00000416779
ENST00000437404
Q5JW28
Show all »
Show » 199 22.5 No 0
STAU1-006 ENSP00000360867
ENST00000371802
O95793
Show all »
Show » 502 55.6 No 0
STAU1-007 ENSP00000360857
ENST00000371792
Q5JW30
Show all »
Show » 494 54.7 No 0
STAU1-008 ENSP00000398785
ENST00000456866
F6UDC6
Show all »
Show » 129 14.7 No 0
STAU1-201 ENSP00000360893
ENST00000371828
O95793
Show all »
Show » 502 55.6 No 0