PCK1

GENE INFORMATION

? »

Gene name

PCK1 (HGNC Symbol)

Synonyms

PEPCK-C

Description

phosphoenolpyruvate carboxykinase 1 (soluble) (HGNC Symbol)

Entrez gene summary

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q13.31

Chromosome location (bp)

56136136 - 56141513

Ensembl

ENSG00000124253 (version 73.37)

Entrez gene

5105

UniProt

P35558 (UniProt - Evidence at protein level)

neXtProt

NX_P35558

Antibodypedia

PCK1 antibodies
 

PROTEIN VIEW

? »
 
 
 
PCK1-001
 
PCK1-201
 
PCK1-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCK1-001 ENSP00000319814
ENST00000319441
P35558
Show all »
Show » Show » 622 69.2 No 0
PCK1-201 ENSP00000444342
ENST00000535860
F5GZM4
Show all »
Show » 313 33.7 No 0
PCK1-202 ENSP00000445767
ENST00000543666
B4DT64
Show all »
Show » 305 34.2 No 0