PEPD

GENERAL INFORMATION

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Gene name

PEPD

Gene description

Peptidase D

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in renal tubules, Leydig cells and glandular cells of gastrointestinal tract and gall bladder. Neuronal and muscle tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA015599
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PEPD

Synonyms

Description

Peptidase D (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Chromosome

19

Cytoband

q13.11

Chromosome location (bp)

33386950 - 33521794

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124299 (version 78.38)

Entrez gene

5184

UniProt

P12955 (UniProt - Evidence at protein level)

neXtProt

NX_P12955

Antibodypedia

PEPD antibodies


PROTEIN BROWSER

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ENST00000244137
 
ENST00000397032
 
ENST00000436370
 
ENST00000588328
 
ENST00000609145
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PEPD-001 ENSP00000244137
ENST00000244137
P12955
Show all »
Show » Show » 493 54.5 No 0
PEPD-002 ENSP00000380226
ENST00000397032
P12955
Show all »
Show » Show » 452 49.7 No 0
PEPD-003 ENSP00000391890
ENST00000436370
P12955
Show all »
Show » Show » 429 47.3 No 0
PEPD-009 ENSP00000468516
ENST00000588328
V9GY89
Show all »
Show » 194 21.6 No 0
PEPD-014 ENSP00000476514
ENST00000609145
V9GY89
Show all »
Show » 104 11.7 No 0