F13A1

GENE INFORMATION

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Gene name

F13A1 (HGNC Symbol)

Synonyms

F13A

Description

coagulation factor XIII, A1 polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p25.1

Chromosome location (bp)

6144318 - 6321246

Ensembl

ENSG00000124491 (version 73.37)

Entrez gene

2162

UniProt

P00488 (UniProt - Evidence at protein level)

neXtProt

NX_P00488

Antibodypedia

F13A1 antibodies
 

PROTEIN VIEW

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F13A1-001
 
F13A1-002
 
F13A1-003
 
F13A1-004
 
F13A1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F13A1-001 ENSP00000264870
ENST00000264870
P00488
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Show » Show » 732 83.3 No 0
F13A1-002 ENSP00000394693
ENST00000445223
Show » 102 11.2 No 0
F13A1-003 ENSP00000413334
ENST00000414279
Q9NQP5
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Show » 138 16 No 0
F13A1-004 ENSP00000416295
ENST00000431222
A6PVK5
Show all »
Show » 186 21 No 0
F13A1-006 ENSP00000411114
ENST00000451619
A0A2H0
Show all »
Show » 147 16.7 No 0