SLC10A2

GENE INFORMATION

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Gene name

SLC10A2 (HGNC Symbol)

Synonyms

ASBT, ISBT

Description

solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

Chromosome

13 (Chromosome progress)

Cytoband

q33.1

Chromosome location (bp)

103696350 - 103719196

Ensembl

ENSG00000125255 (version 73.37)

Entrez gene

6555

UniProt

Q12908 (UniProt - Evidence at protein level)

neXtProt

NX_Q12908

Antibodypedia

SLC10A2 antibodies
 

PROTEIN VIEW

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SLC10A2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC10A2-001 ENSP00000245312
ENST00000245312
Q12908
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