ABCC4

GENE INFORMATION

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Gene name

ABCC4 (HGNC Symbol)

Synonyms

EST170205, MOAT-B, MOATB, MRP4

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

13

Cytoband

q32.1

Chromosome location (bp)

95019829 - 95301433

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125257 (version 78.38)

Entrez gene

10257

UniProt

O15439 (UniProt - Evidence at protein level)

neXtProt

NX_O15439

Antibodypedia

ABCC4 antibodies
 

PROTEIN VIEW

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ABCC4-001
 
ABCC4-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC4-001 ENSP00000366084
ENST00000376887
O15439
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Show » Show » 1325 149.5 No >9
ABCC4-006 ENSP00000442024
ENST00000536256
B7Z3Q7
Show all »
Show » Show » 784 88.1 No 6