ABCC4

GENERAL INFORMATION

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Gene name

ABCC4

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Protein class

Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (prostate)
GTEx:Tissue enhanced (urinary bladder)

Protein evidence

Evidence at protein level

Protein localization

Membranous expression in prostate glands.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 1 antibody.
HPA002476
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (prostate)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (urinary bladder)

Organ

Expression



GENE INFORMATION

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Gene name

ABCC4 (HGNC Symbol)

Synonyms

EST170205, MOAT-B, MOATB, MRP4

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

13

Cytoband

q32.1

Chromosome location (bp)

95019829 - 95301433

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125257 (version 78.38)

Entrez gene

10257

UniProt

O15439 (UniProt - Evidence at protein level)

neXtProt

NX_O15439

Antibodypedia

ABCC4 antibodies


PROTEIN BROWSER

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ENST00000376887
 
ENST00000536256
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC4-001 ENSP00000366084
ENST00000376887
O15439
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Show » Show » 1325 149.5 No >9
ABCC4-006 ENSP00000442024
ENST00000536256
B7Z3Q7
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Show » Show » 784 88.1 No 6