BMP4

GENE INFORMATION

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Gene name

BMP4 (HGNC Symbol)

Synonyms

BMP2B

Description

bone morphogenetic protein 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

54416454 - 54425479

Ensembl

ENSG00000125378 (version 73.37)

Entrez gene

652

UniProt

P12644 (UniProt - Evidence at protein level)

neXtProt

NX_P12644

Antibodypedia

BMP4 antibodies
 

PROTEIN VIEW

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BMP4-001
 
BMP4-002
 
BMP4-003
 
BMP4-004
 
BMP4-006
 
BMP4-007
 
BMP4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMP4-001 ENSP00000245451
ENST00000245451
P12644
Show all »
Show » Show » 408 46.6 Yes 0
BMP4-002 ENSP00000453485
ENST00000559087
P12644
Show all »
Show » Show » 408 46.6 Yes 0
BMP4-003 ENSP00000454134
ENST00000558984
P12644
Show all »
Show » Show » 408 46.6 Yes 0
BMP4-004 ENSP00000453467
ENST00000559642
H0YM53
Show all »
Show » 110 12.3 Yes 0
BMP4-006 ENSP00000453365
ENST00000559501
H0YLW3
Show all »
Show » 271 31.6 No 0
BMP4-007 ENSP00000453691
ENST00000558961
H0YMP9
Show all »
Show » 104 11.9 No 0
BMP4-201 ENSP00000394165
ENST00000417573
P12644
Show all »
Show » Show » 408 46.6 Yes 0