IL1B

GENE INFORMATION

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Gene name

IL1B (HGNC Symbol)

Synonyms

IL-1B, IL1-BETA, IL1F2

Description

interleukin 1, beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q13

Chromosome location (bp)

113587328 - 113594480

Ensembl

ENSG00000125538 (version 73.37)

Entrez gene

3553

UniProt

P01584 (UniProt - Evidence at protein level)

neXtProt

NX_P01584

Antibodypedia

IL1B antibodies
 

PROTEIN VIEW

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IL1B-001
 
IL1B-003
 
IL1B-006
 
IL1B-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1B-001 ENSP00000263341
ENST00000263341
P01584
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Show » Show » 269 30.7 No 0
IL1B-003 ENSP00000407219
ENST00000418817
C9JWV2
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Show » 143 16.4 No 0
IL1B-006 ENSP00000400854
ENST00000416750
C9JVK0
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Show » 111 12.8 No 0
IL1B-007 ENSP00000409680
ENST00000432018
C9JSC2
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Show » 125 14.3 No 0