MED1

GENE INFORMATION

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Gene name

MED1 (HGNC Symbol)

Synonyms

CRSP1, CRSP200, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2

Description

mediator complex subunit 1 (HGNC Symbol)

Entrez gene summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

37560538 - 37607539

Ensembl

ENSG00000125686 (version 73.37)

Entrez gene

5469

UniProt

Q15648 (UniProt - Evidence at protein level)

neXtProt

NX_Q15648

Antibodypedia

MED1 antibodies
 

PROTEIN VIEW

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MED1-001
 
MED1-002
 
MED1-003
 
MED1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MED1-001 ENSP00000300651
ENST00000300651
Q15648
Show all »
Show » Show » 1581 168.5 No 0
MED1-002 ENSP00000377828
ENST00000394287
Q15648
Show all »
Show » Show » 556 61.6 No 0
MED1-003 ENSP00000463307
ENST00000577831
J3QKZ7
Show all »
Show » 97 11 No 0
MED1-005 ENSP00000462441
ENST00000581334
J3KSD7
Show all »
79 9.2 No 0