PSMB2

GENE INFORMATION

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Gene name

PSMB2 (HGNC Symbol)

Synonyms

HC7-I

Description

proteasome (prosome, macropain) subunit, beta type, 2 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

1 (Chromosome progress)

Cytoband

p34.3

Chromosome location (bp)

36067185 - 36107445

Ensembl

ENSG00000126067 (version 73.37)

Entrez gene

5690

UniProt

P49721 (UniProt - Evidence at protein level)

neXtProt

NX_P49721

Antibodypedia

PSMB2 antibodies
 

PROTEIN VIEW

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PSMB2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB2-001 ENSP00000362334
ENST00000373237
P49721
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