F10

GENE INFORMATION

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Gene name

F10

Synonyms

Description

coagulation factor X (HGNC Symbol)

Entrez gene summary

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]

Chromosome

13 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

113777128 - 113803843

Ensembl

ENSG00000126218 (version 73.37)

Entrez gene

2159

UniProt

P00742 (UniProt - Evidence at protein level)

neXtProt

NX_P00742

Antibodypedia

F10 antibodies
 

PROTEIN VIEW

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F10-001
 
F10-002
 
F10-006
 
F10-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F10-001 ENSP00000364709
ENST00000375559
P00742
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Show » Show » 488 54.7 Yes 0
F10-002 ENSP00000364701
ENST00000375551
Q5JVE8
Show all »
Show » Show » 332 37.1 Yes 0
F10-006 ENSP00000386320
ENST00000410083
F8WBM7
Show all »
Show » Show » 130 14.8 Yes 0
F10-007 ENSP00000387092
ENST00000409306
B7ZBK1
Show all »
Show » Show » 334 37.3 Yes 0