BCL2L12

GENE INFORMATION

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Gene name

BCL2L12

Synonyms

Description

BCL2-like 12 (proline rich) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

19 (Chromosome progress)

Cytoband

q13.33

Chromosome location (bp)

50168823 - 50177173

Ensembl

ENSG00000126453 (version 73.37)

Entrez gene

83596

UniProt

Q9HB09 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HB09

Antibodypedia

BCL2L12 antibodies
 

PROTEIN VIEW

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BCL2L12-001
 
BCL2L12-002
 
BCL2L12-004
 
BCL2L12-005
 
BCL2L12-006
 
BCL2L12-008
 
BCL2L12-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2L12-001 ENSP00000246785
ENST00000246785
Q9HB09
Show all »
Show » 334 36.8 No 0
BCL2L12-002 ENSP00000393803
ENST00000441864
Q9HB09
Show all »
Show » 333 36.7 No 0
BCL2L12-004 ENSP00000469216
ENST00000594157
131 13.8 No 0
BCL2L12-005 ENSP00000471919
ENST00000598979
131 13.8 No 0
BCL2L12-006 ENSP00000470644
ENST00000600947
164 17.8 No 0
BCL2L12-008 ENSP00000472214
ENST00000598306
M0R1Z8
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113 12.6 No 0
BCL2L12-201 ENSP00000246784
ENST00000246784
Q9HB09
Show all »
Show » 176 19.1 No 0