PRKCG

GENE INFORMATION

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Gene name

PRKCG (HGNC Symbol)

Synonyms

MGC57564, PKCC, PKCG, SCA14

Description

protein kinase C, gamma (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.42

Chromosome location (bp)

54382444 - 54410906

Ensembl

ENSG00000126583 (version 73.37)

Entrez gene

5582

UniProt

P05129 (UniProt - Evidence at protein level)

neXtProt

NX_P05129

Antibodypedia

PRKCG antibodies
 

PROTEIN VIEW

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PRKCG-001
 
PRKCG-004
 
PRKCG-005
 
PRKCG-006
 
PRKCG-201
 
PRKCG-202
 
PRKCG-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCG-001 ENSP00000263431
ENST00000263431
P05129
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Show » Show » 697 78.4 No 0
PRKCG-004 ENSP00000471544
ENST00000479081
M0R0Z4
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19 2.2 No 0
PRKCG-005 ENSP00000471271
ENST00000474397
M0R0I9
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Show » 100 11.4 No 0
PRKCG-006 ENSP00000387919
ENST00000419486
H7BZ60
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Show » 35 4.1 No 0
PRKCG-201 ENSP00000440541
ENST00000536044
B7Z870
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Show » 327 36.3 No 0
PRKCG-202 ENSP00000443493
ENST00000540413
F5H5C4
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Show » Show » 710 79.8 No 0
PRKCG-203 ENSP00000438090
ENST00000542049
B7Z8Q0
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Show » Show » 548 62 No 0