DACH2

GENERAL INFORMATION

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Gene name

DACH2

Gene description

Dachshund family transcription factor 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, fallopian tube)
GTEx:Tissue enhanced (cerebral cortex, hippocampus)

Protein evidence

Evidence at transcript level

Protein localization

Nuclear expression in CNS and fallopian tube.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists.

Data reliability

Uncertain based on 1 antibody.
HPA000258
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, fallopian tube)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

DACH2

Synonyms

Description

Dachshund family transcription factor 2 (HGNC Symbol)

Entrez gene summary

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Chromosome

X

Cytoband

q21.2

Chromosome location (bp)

86148458 - 86832604

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000126733 (version 78.38)

Entrez gene

117154

UniProt

Q96NX9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q96NX9

Antibodypedia

DACH2 antibodies


PROTEIN BROWSER

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ENST00000373125
 
ENST00000373131
 
ENST00000484479
 
ENST00000508860
 
ENST00000510272
 
ENST00000613770
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DACH2-001 ENSP00000362223
ENST00000373131
Q96NX9
Show all »
Show » Show » 571 61.9 No 0
DACH2-002 ENSP00000421919
ENST00000510272
Q96NX9
Show all »
Show » Show » 380 41.8 No 0
DACH2-004 ENSP00000422727
ENST00000484479
H0Y912
Show all »
Show » 249 27.8 No 0
DACH2-006 ENSP00000420896
ENST00000508860
Q96NX9
Show all »
Show » Show » 432 47.2 No 0
DACH2-007 ENSP00000362217
ENST00000373125
Q96NX9
Show all »
Show » Show » 599 65.3 No 0
DACH2-201 ENSP00000478116
ENST00000613770
Show » 427 46.5 No 0