CFP

GENE INFORMATION

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Gene name

CFP (HGNC Symbol)

Synonyms

PFC

Description

complement factor properdin (HGNC Symbol)

Entrez gene summary

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

Chromosome

X (Chromosome progress)

Cytoband

p11.23

Chromosome location (bp)

47483612 - 47489704

Ensembl

ENSG00000126759 (version 73.37)

Entrez gene

5199

UniProt

P27918 (UniProt - Evidence at protein level)

neXtProt

NX_P27918

Antibodypedia

CFP antibodies
 

PROTEIN VIEW

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CFP-001
 
CFP-002
 
CFP-006
 
CFP-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CFP-001 ENSP00000380189
ENST00000396992
P27918
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Show » Show » 469 51.3 Yes 0
CFP-002 ENSP00000366204
ENST00000377005
E9PAQ1
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Show » 415 45.1 Yes 0
CFP-006 ENSP00000418258
ENST00000469388
C9J7V5
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167 17.6 No 0
CFP-201 ENSP00000247153
ENST00000247153
P27918
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Show » Show » 469 51.3 Yes 0